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Immunotherapies for tumors, such as antibodies, cytokine immune checkpoint inhibitors, and cancer vaccines have demonstrated clinical efficacy and are promising strategies against cancer (Sharma et al., 2017)

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Br J Clin Pharmacol 22:100103 Hamer HM, Knake S, Schomburg U et al (2000) Valproate-induced hyperammonemic encephalopathy in the presence of topiramate

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Clinical studies in humans generally report good tolerability, but safety assessments are often limited by small sample sizes and short-to-moderate intervention durations, which may not capture rare or long-term adverse outcomes [86]